Los ácidos micólicos, en específico, poseen funciones biológicas importantes, entre las que se encuentra el papel que desempeñan en la persistencia de la. como los ácidos micólicos, ácido micoserósido, fenoltiocerol, lipoarabinomanano y arabinogalactano contribuyen a la longevidad, a la respuesta inflamatoria. Aunque el análisis de los lípidos de la pared celular (ácidos micólicos) mediante cromatografía líquida de alta presión es una opción Buena y bien conocida, los.

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Ciudad de la Habana, Cuba. Fatty acid biosynthesis is a prokariontes and eucariontes biochemical process that supplies essential precursors for the assembly of important cellular components, such as phospholipids, lipoproteins, lipopolysaccharides, mycolic acids and cellular envelope.

A lipid extract of Mycobacterium smegmatis cell wall was characterized using a Thin Layer Chromatography and Dot blot with human gammaglobulin. Nat Rev Microbiol ; 4: Single nucleotide polymorphisms in genes associated with isoniazid resistance in Mycobacterium tuberculosis.

Constructing protein models for ligand-receptor binding thermodynamic simulations: The mabA gene from the inhA operon of Mycobacterium tuberculosis encodes a 3-ketoacyl reductase that fails to confer isoniazid resistance. A triclosan-resistant bacterial enzyme. Effect of Mycobacterial phospholipids on interaction of Mycobacterium tuberculosis with macrophages. Molecular Microbiology ; J Biol Chem ; Lepr Rev ; 68 4: Characterization of a ligand-receptor binding event using receptor-dependent four-dimensional quantitative structure-activity relationship analysis.


Services on Demand Journal. Infect Dis Clin N Am ; Chemotherapy of experimental tuberculosis – VI.

The synthesis of acid hydrazides, their derivatives and related compounds. Rational approach in the new antituberculosis agent design: The practice of medicinal chemistry.

Global tuberculosis control – surveillance, planning, financing. La pared celular de M.

Mechanism of action of diazaborines. Enzymatic characterization of the target for isoniazid in Mycobacterium tuberculosis. How to cite this article. Implications of multidrug resistance for the future of short-course chemotherapy of tuberculosis: J Exp Med ; Heterocyclic acid hydrazides and derivatives.

In conjunction with the spread of HIV infection, tuberculosis TB has been among the worldwide health threats. The catalase-peroxidase gene and isoniazid resistance of Mycobacterium tuberculosis. Rational design of new antituberculosis agents: Transfer of a point mutation in Mycobacterium tuberculosis inhA resolves the target of isoniazid.

Microbial pathogenesis of Mycobacterium tuberculosis: Critical review of the role of HTS in drug discovery.

Ácido micólico – Wikipedia, a enciclopedia libre

Bishop PJ, Neumann G. Discovery of a novel and potent class of FabI-directed antibacterial agents. Mechanistic diversity and regulation of Type II fatty acid synthesis.

Transmission and protection in leprosy: Estes pesquisadores isolaram cepas de E.

Biosynthesis of mycobacterial lipoarabinomannan: Water Res ; Mainly we identified the presence of phospholipids and micolic acids in the lipid extract showing a high recognition by human gammaglobulin.


De acuerdo con los resultados obtenidos mediante el empleo de la cromatografia en capa delgada y el Dot blot, se puede afirmar que se obtuvo un extracto de pared de M. Drug sensitivity and environmental adaptation of mycobacterial cell wall components. Chemoterapy of experimental tuberculosis.

Ácido micólico

Tal es el caso del estudio desarrollado por Mederos y cols. The mechanism of isoniazid killing: Crometografia en capa delgada de fosfolipidos extraidos de Mycobacterium smegmatis. Cepa bacteriana acidls condiciones de crecimiento. Drug Targetsv. Inhibitors of fatty acid synthesis as antimicrobial chemotherapeutics. Infection and Immunity ; De estudios sobre virulencia hacia herramientas para su control.

In view of this severe situation, the new and selective anti-TB design is of utmost importance. Overexpression of inhA, but not kasAconfers resistance to isoniazid and ethionamide in Mycobacterium smegmatisM. Some observations on mcolicos pathogenicity of isoniazid-resistant variants of tubercle bacilli.