An ameloblastic fibroma is a fibroma of the ameloblastic tissue, that is, an odontogenic tumor arising from the enamel organ or dental lamina. It may be either. Ameloblastic fibroma, is a mixed odontogenic tumor, which commonly affects young children under the age of 20 years, with the mandibular premolar-molar. ameloblastic fibroma in a 9-year-old boy has been presented along with a review of the literature. The tumor responded to conservative surgical treatment.

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AFs are classified based on histology as granular cell type, where granular cells predominate in ectomesenchyme, papilliferous with marked proliferation of the epithelium [ 4 ], ameloblastoma in association with AF and cystic ameloblastoma [ 21 ]. Mixed odontogenic tumors and odontomas: For these reasons, despite many similarities, it is essential to differentiate the ameloblastic fibroma from other mixed odontogenic lesions because it has true neoplastic qualities.

Males show a slightly higher prediction than females M: In addition to detecting the mitotic figures in the histology, immunohistochemical analysis using ki, PCNA, and p53 labelling indices would further aid in delineating AFS from AF [ 28 ].

Report of 3 cases and literature review. AFs usually present with a well-defined unilocular or multilocular radiolucencies [ 7 ].

Ameloblastic fibroma

Ameloblawtic clinical and radiographic clues are used to narrow the diagnosis. Unilocular lesions are predominantly asymptomatic, while the multilocular cases are often associated with jaw swelling [ 8 ].

Surgical excision or thorough curettage with removal of affected teeth is the treatment of choice [ 12 ]. Ameloblastic fibroma in one-year-old girl. Patient had identified the enlargement 8 months back and her medical history was unremarkable.

In addition, odontogenic amelolbastic may present diffuse calcifications Critical analysis fihroma previously reported cases plus 10 new cases. Thus, this report describes a case of AF appearing as mixed radiographic image, which was identified as incidental finding. Extensive ameloblastic fibroma of the mandible: Radiographically, ameloblastic fibromas are unilocular lesions, occasionally multilocular when larger, with smooth well-demarcated borders.


Our case of AF with high cellularity is unusual in the context of its histopathology. Treatment The area was treated with thorough curettage and the associated maxillary second molar was extracted. Ossifying fibroma, extra-follicular variant of adenomatoid odontogenic tumor, calcifying cystic odontogenic tumor, calcifying epithelial odontogenic tumor, and myxoma were the main hypotheses of diagnosis.

Histopathological picture Click here to view.

The diagnosis of AF was established. Additionally, in the current case, the tumor was located between the roots of the left mandibular second premolar and first molar, causing a diastema between these teeth. This report describes a case of AF in a year-old male identified during a routine radiographic exam for orthodontic treatment planning. Cohen DM, Bhattacharyya I. How to cite this URL: The recurrence rate varies among sources, but is considered to be low [ 57 ]. How to cite this article: Ameloblastic sarcoma of the mandible.

A careful treatment planning is necessary considering their recurrence rate and ability to undergo malignant transformation. Calcifying epithelial odontogenic ameloblstic Hansen LS, Ficarra G.

Several spindle-shaped cells and abundant extracellular matrix deposition were found between the islands of neoplastic cells HE, x Case Reports in Pediatrics.

Normal eruption of the teeth in the affected fubroma is usually altered with more than one-third of cases associated with an impacted tooth [ 21 ]. Patients often present with painless swelling of the jaw and the lesion may affect the normal eruption of teeth in the area. A slight male predilection has been noted [ 45 ].

Ameloblastic fibroma: A rare case appearing as a mixed radiographic image

This controversy further attributes to the difficulties to differentiate between the histology of the neoplastic and the hamartomatous lesions with the histologic features of ameloblastic fibroma [ 4 ]. Sitemap What’s New Feedback Disclaimer.


Mitoses should not be a feature of ameloblastic fibroma [ 13 ]. Well-defined unilocular ameloblastif prohibiting the eruption of the left maxillary second molar.

An analysis of the interrelationship of the mixed odontogenic tumors: A fine-needle aspiration case report. A year-old female patient came to the Department of Oral Medicine and Radiology with a chief complaint of slowly progressive swelling on the right side of her lower posterior jaw.

Ameloblastic fibroma

Review of the literature and presentation of new cases of odontomas. Open Access This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author s and source are credited. Complex epithelial Warthin’s tumor Thymoma Bartholin gland carcinoma. Radiographically, AF appears as a well-defined, unilocular or multilocular radiolucent lesion, with sclerotic radiopaque margins 34.

Microscopically AFs are composed of both the epithelial and connective tissue components; the later appears to recapitulate dental papilla made up of spindled and ameloblastlc cells with delicate collagen, imparting a myxomatous appearance.

The lesion was enucleated and sent for histopathological examination. A narrow cell-free zone bordering the epithelium and juxta-epithelial hyalinization in the connective tissue, which ultrastructurally may represent exuberant basal lamina with or without resemblance to early stage of normal odontogenesis was noted [ 2526 ]. Although rare, AF should be considered in the differential diagnosis of mixed lesions of the jaws in patients during childhood and adolescence.

A review of published studies with special ameloblastix to its nature and biological behavior. Mitotic activity was not appreciated. Open in a separate window. Glandular and epithelial neoplasms ICD-O