Ecarin is a snake venom (Echis carinatus) that directly activates prothrombin to meizothrombin This action is not dependent on phospholipid membranes and . Objective(s): Echis carinatus is one of the venomous snakes in Iran. The venom of Iranian Echis carinatus is a rich source of protein with various factors affecting . In this research, the effects of Echis carinatus crude venom and its fractions on mice were analyzed. Moreover, the results of coagulation tests.

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The results when compared to a general acute toxicity index were normal, and no acute toxicity was observed. How to interpret and pursue an abnormal prothrombin time, activated partial thromboplastin time, and bleeding time in adults.

About an hour after injection, blood samples were collected. The present research project was conducted under the supervision of Razi Vaccine and Serum Research Institute and the results described in this paper were part of the student thesis, which was performed with supervision of Dr Hossein Zolfagharian and a scientific collaboration of Razi Institute and the University.

Table 2 PT value for fractions of I Ec crude venom. Plants used as remedy for snakebite abound in literature [ 20 — 23 ]. By using this site, you agree to the Terms of Use and Privacy Policy. Coagulant Activity The plasma coagulation property was determined according to the method of Theakston and Reid [ 18 ] with minor modification.


Snake venom of Echis carinatus sochureki – Latoxan

The total protein of crude venom of E. Abstract The objective of the study is to investigate the anti-snake venom activities of a local plant, Hibiscus aethiopicus L.

In vitro effects of Echis carinatus venom on the human plasma proteome. Please review our privacy policy. Source of Venoms The venom of E. There are ventral scales that are rounded vemom cover the full width of the belly. The extract was found to inhibit, dose dependently, the procoagulant activity of the E. Can grow to a maximum of about 0. Paul Rowley for providing the snake venom.

In this study we have used H. Local symptoms include swelling and pain, which rchis within minutes of a bite. There are interocular scales across the top of the head and circumorbital scales.

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Copyright ToxinologyWCH. The ion exchange chromatography 1. We also thank Mr. Some procoagulant factors, along with its molecular weights, have been reported by Howes JM et al in addition to the effects of three novel metalloproteinases weighting 56 kDa from the venom of the West African saw-scaled viper, E.

This obviously would need further investigations for both systemic and local evaluation.

The inset shows the dose-dependent procoagulant activity of E. All the three metalloproteinases were able to activate prothrombin and to convert it into different fractions [ 30 ]. Such effects include severe pain, oedema, localized haemorrhage, and necrosis [ 5 ] which often results in permanent scarring and deformity. Purification and properties of a prothrombin activator from the venom of Notechis scutatus scutatus. Moreover, this result can also suggest that having the extract before envenomation can act as a prophylactic agent.


Plant-derived drugs remain important resource to combat serious diseases. Protein determination The total protein of crude venom of E. It seems the fraction F 1 B 4 isolated from I Ec to be like ecarin which is already reported.

Antivenom Therapy Antivenom is the key treatment for systemic envenoming. Interestingly in this study we found that the extract can inhibit dose dependently vfnom procoagulant activity of the E. In addition to the coagulation assay, we examined the neutralisation of the extract against the oedema inducing activity of the E.

At lower concentrations, small clots are formed snwke coagulation time vemom longer, whereas at higher concentrations, larger clots are found and coagulation time is shorter [ 21 ]. Venom Haemorrhagins Zinc metalloproteinase. This rapid response of the coagulation cascade occurs in the animal body and generates clinical effects such as coagulopathy, which may provoke death. Author information Article notes Copyright and License information Disclaimer.

Habits Mainly nocturnal, but fond of basking in the scorching midday heat.