MASCULINO EJE HIPOTÁLAMO-HIPÓFISIS-GONADAL GnRH LH & FSH Glucoproteínas Sistema 2° Mensajero AMPc (Blancos) Leydig-LH. Se inicia en el sistema nervioso central por factores neuroendocrinos que activan el eje hipotálamo-hipofisario-gonadal y sus mecanismos reguladores. hipotálamo que permite a la hipófisis liberar las gonadotrofi- nas, la GnRH, cuyo . Ambas hormonas, favorecen la maduración gonadal y la esteroidogénesis .. ditismo masculino (insensibilidad parcial a los andrógenos,. [síndrome de GnRH, resulta en una ablación completa del eje reproductivo. Las implicaciones .

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Licea Puig hipofisario y Dra. En este cuadro confluyen cambios bio-psicosociales-ambientales. A medida que el hombre envejece las concentraciones de DHT disminuyen. En estos casos se ha comprobado que la THR normaliza los valores de leptina. Este preparado ocasiona con frecuencia trastornos estomacales. La dosis administrada fue de mg diario por 3 semanas. Resultados similares han sido obtenidos por otros autores. Se administran en dosis de masculono cada 2 a 4 semanas. Son efectivos en elevar los niveles de T hasta la normalidad.

Tiene la ventaja de reproducir el ciclo circadiano de la T y no tener efectos significativos sobre la eritropoyesis. Su alto costo limita su uso generalizado. Cuestionario aplicado en la Universidad de San Louis, Missouri.

The presence of andropause in man as mmasculino expression of the decline of testosterone secretion is still a topic of discussion. The usefulness of hormone replacement therapy in these persons is also a cause of controversy. A review is made of some aspects of masculin related to the definition, clinical manifestations, impact in the quality of life, and treatment of andropause, which is an insidious and slow process resulting from a gradual reduction of testosterone secretion. Biological, psychological, social, and environmental changes converge in this picture.

Andropause is accompanied with hormonal alterations that are considered as responsible for the symptoms and clinical signs. Andropause has adverse effects on physical, mental and social health that bring about a deterioration of the quality of life.


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For some individuals, the hormone replacement therapy may revert the clinical manifestations and significantly improve the quality of life. However, other researchers discussed about the real indication of this therapeutic procedure, its advantages and disadvantages.

It is concluded that the terms andropause and hormone replacement therapy are a topic of discussion nowadays, and it is necessary to conduct a long term study to accurately define its clinical picture and the advantages and disadvantages of hormone replacement therapy. Andropause, male climacteric, sexual dysfunction, male menopause, hormone replacement therapy, androgens, testosterone. Impact of obesity on hipogonadism in the andropause.

Juul A, Skakkeback NF. Androgen and the aging male. Andropause, a misnomer hipofjsiario a true clinical entity. Neuroendocrine aging in men. Endocrinol Metab Clin North Am.

Sexuality of the elderly. Percepcions of risk factors for andropause. Andropenia and goadal therapy in men. Aging related decline of gonadal function in healthy men: J Am Geriatric Soc.

Contribution of body fatness and adipose tissue distribution to the age variation in plasma steroid hormone concentrations in men.

J Clin Endocrinol Metab. Sexual medicine aspects of the aging man. Intern J Impot Res. Hormone profile in the aging man. Sex differences in the association of endogenous sex hormone levels and glucose tolerance status in older men and women. Temporal relation between obesity and insulin: Constructions and field validation of a self administered screener for testosterone deficiency hypogonadism in ageing men.

Vermeulen A, Kaufman JM. Ageing of hypothalamo-pituitary-testicular axis in men. Testosterone, body composition and aging.

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Lower endogenous androgen levels and dyslipidemia in men with non-insulin -dependent diabetes mellitus. Low dehydroepiandrosterone and ischemic heart disease in middle-aged men: Serum leptin levels in healthy ageing men: Testosterone and leptin in older African-American men: Aromatase, adiposity, aging and disease. The hypogonadal metabolic atherogenic disease and aging connection. Marin P, Arver S. Androgen and abdominal obesity. Bellieres Clin Endocrinol Metab ; Hiperinsulinismo como factor de riesgo cardiovascular.

Testosterone replacement therapy in older adult men. Sex hormones and age: The andropause amd memory loss: Memory loss as reported symtom of androgenopause.


Andropause and quality of life: Findings from patient focus groups and clinical experts. Validation of screning questionnaire for androgen deficiency in aging males. Quality of life issue in the aging male.

The aging male ; 3: Inte J Impot Res ;15 Suppl 4: Testosterone replacement therapy for aging men. Serum androgen bioactivity during 5-alpha- dihydrotestosterone treatment in erderly men. Prevalence and manegement of mild hypogonadism: Int J Impot Res. Androgen treatment of male hypogonadism in older men. J Steroid Biochen Mol Biol. Declining testicular function in egeing men. Basaria S, Dobs AS. Risk versus beneficts of testosterone therapy in elderly men.

Testosterone supplementation therapy for older men: J Am Geriatr Soc. Testosterone and depression in men age over 50 years. Andropause and psychopathology minimal systemic work up.

Carbone DJ, Hodges S. Medical therapy for bening prostate hyperplasia: Bhasin S, Buckwalter JG. Testosterone supplement entation in older men: Outcomes of longterm testosterone replacement in older hypogonadalmale: Transdermal testosterone gel improves sexual function, mood, muscle strength and body composition parameters in hypogonadal men.

Wespes E, Schulman CC. Int J Impot Suppl 1: Juul A, Skakkebaek NE. Testosterone treatment of eldely man. The so called andropause doesn’t exist. Testosterone reemplacement therapy for againg men.

Morales A, Heaton J. Hormonal erectile dysfunction- evaluation and manegement. Urol Clin North Am. Wang C, Swerdloff RS.

eje hipotalamo hipofisiario gonadal masculino pdf

Should the nonaromatizable androgen dihydrotestosterone be considerated as an alternative to testosterone in treatment of andropause? Clinical implications of the decline in serum testosterone levels with againghim men. The effects of transdermal dehydrotestostere in the aging male: A prospective, randomized, double blind study. Knowledge and perceptions among the general public and health care professionals.

Shabasigh R, Hypogonadism and erectile dysfunction: