Elastosis perforans serpiginosa (EPS) is a rare disorder classified as a primary perforating dermatosis. That group of diseases also includes. Four types of elastosis perforans serpiginosa (EPS) have been described in literature: 1) idiopathic EPS, 2) reactive perforating elastosis. Elastosis perforans serpiginosa (EPS) is a rare dermatologic condition where connective and elastic tissues are viewed as foreign objects and subsequently.

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EPS is more commonly reported in men and usually occurs during childhood or early adulthood segpiginosa. Multiple therapies have been reported to be effective in the management of EPS. Many elastic fibers were noted to be elastsis through epidermal channels Figure 1a finding that was consistent with the clinical diagnosis of elastosis perforans serpiginosa EPS. Histopathology of the Skin.

An elastic stain demonstrated an increased concentration of elastic fibers in the middermis extending to the epidermis.

Elastosis perforans serpiginosa: a review of the literature and our own experience

This article has been cited by other articles in PMC. The biopsy specimen demonstrated clawlike downgrowths of epidermis surrounding collections of amorphous basophilic debris and hyperplastic elastic fibers. Tazarotene is the first receptor-selective topical retinoid approved for the treatment of plaque psoriasis. On examination, multiple crusted erythematous papules 2 to 5 mm in size were arranged in an annular and serpiginous pattern Fig.


The cause of abnormal elastic tissue is unknown but may be from a genetic mutation or external factors such as penicillamine.

Elastosis Perforans Serpiginosa

Verhoeff-van Gieson staining showed dense clumps of altered elastic fibers in the papillary dermis. On examination, the patient serpiginksa multiple crusted and erythematous papules arranged in an annular pattern with central clearing. What is standard of care in the evaluation of elastosis perforans serpiginosa? Elastosis perforans serpiginosa, Therapeutics. Her medical history revealed that she had been treated with D-penicillamine for Wilson disease for more than 20 years.

Verhoeff-van Gieson staining showed a markedly increased number of altered elastic fibers forming dense clumps in the upper dermis Fig. Table 1 Diseases associated with elastosis perforans serpiginosa. The patient was treated unsuccessfully with cryotherapy approximately 6 times; high-potency topical corticosteroids, including clobetasol and halobetasol, for 6 weeks; topical 0.

However, to date, the candidate gene has not been identified [ 68 ].

Increased elastic tissue and solar elastotic syndromes. We can distinguish three subtypes of EPS.

The data from the five Korean patients with EPS further support these findings: National Center for Biotechnology InformationU. Cutaneous keratosis, ulcer, atrophy, and necrobiosis L82—L94— This condition is inherited in an autosomal dominant manner. EPS occurs because the epidermis the outer layer of the skin perceives abnormal elastic tissue to be a foreign object, thus responding through an inflammatory attack. The lesions developed 1 month after a revised facial rhytidectomy scar revision.

Response of elastosis perforans serpiginosa to pulsed CO2, Er: How to cite this URL: However, others, like Saxena did not show a positive response to numerous sessions using these lasers, and in turn, CO 2 laser caused scarring [ 16 ]. A case serpigginosa elastosis perforans serpiginosa.


Copyright American Medical Association. There are also conflicting reports about the positive therapeutic effect of laser therapy, including CO 2 laser, Er: Get free access to newly published articles.

Elastosis perforans serpiginosa | DermNet NZ

However, the irritation subsided after a few weeks of therapy. Patient 1 after 2 months of treatment with 0. J Am Acad Dermatol. From Wikipedia, the free encyclopedia. Elastic fibers perforate through the epidermis in patients with EPS. Many of the elastic fibers appeared clumped and thickened.

Purchase access Subscribe to JN Learning for one year. In addition, the patient was suffering from hypothyroidism, tetralogy of Fallot and bilateral congenital dislocation of the hip joints.

Elastosis perforans serpiginosa EPS is a rare skin condition characterized by hyperkeratotic perflrans, transepidermal elimination of abnormal elastic fibers, and focal dermal elastosis. Laser treatment, including carbon dioxide laser and Er: The lesions were fusing into an annular arrangement, spreading outwards and leaving erythematous macule in the center Figures 1 A, B.

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