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Directory of Open Access Journals Sweden. To describe the methodology used for implementing a surveillance system specifically for influenza A H1N1pdm09 in the French West Indies and French Guiana during an outbreak of this new virus inand to report its main results. This was an observational descriptive study of confirmed and probable cases of influenza A H1N1pdm09 hospitalized for at least 24 hours in 23 July March Reverse transcription polymerase chain reaction was performed on nasopharyngeal swab samples according to fundamrntos Centers for Disease Control and Prevention protocol.

All confirmed and probable hospitalized cases were reported, along with patient’s age, sex, clinical condition at admission, place and length of hospitalization, antiviral treatment, underlying conditions, complications, and clinical evolution.

A case was classified as severe if respiratory assistance or intensive care was required or if death resulted. A total of confirmed and 16 probable cases were hospitalized, with a hospitalization rate ranging from 4.

Of these, 36 were severe, and subsequently, 10 were fatal. No Brasil, foram confirmados Inthe emergence of cases of influenza A H1N1 – the popular flu – in countries indicated the registration of the first pandemic of the XXI century, as predicted in reports from health authorities some years ago.

The media have linked the emergence of flu as a. Full Text Available Objetivos: To describe the prevalence of influenza-like syndrome in winter and the factors associated with its occurrence. A cross-sectional study was carried out in 18 hospitals in Spain.

Volunteers completed a health questionnaire in which they reported the occurrence of influenza-like syndrome and vaccination and demographic status. A total of 1, healthcare workers participated. Of these, 72 5. Fndamentos were differences among regions. In logistic regression analysis, the following factors were associated with a higher prevalence of influenza-like syndrome: Evolutionary trends of A H1N1 influenza virus hemagglutinin since Although the symptoms in humans are mild at present, fears are that further mutations in the virus could lead to a potentially more iairo outbreak in subsequent months.

As the primary immunity-eliciting antigen, hemagglutinin HA is the major agent for host-driven antigenic drift in A H3N2 virus. However, whether and how the evolution of HA is influenced by existing immunity is poorly understood for A H1N1.

Among a subgroup of human A H1N1 HAs between approximatelywe found strong diversifying positive selection at HA 1 and We also analyzed the evolutionary trends fundamdntos HA 1 and that are critical determinants for receptor-binding specificity of A H1N1 HA.

Different A H1N1 viruses appeared to favor one of these two sites in host-driven antigenic drift: Thus, our results highlight the urgency to understand the interplay between antigenic drift fundamsntos receptor binding in HA evolution, and provide molecular signatures for monitoring future antigenically drifted pandemic and seasonal A H1N1 influenza viruses.

The emergence of the H1N1 pandemic influenza virus [A H1N1pdm09] has provided the public health community with many challenges, but also the scientific community with an opportunity to monitor closely its evolution through the processes of drift and shift.

To date, and despite having circulated in humans for nearly two years, little antigenic variation has been observed in the A H1N1pdm09 viruses. However, as the A H1N1pdm09 virus continues to circulate and the immunologic pressure within the human population increases, future antigenic change is almost a certainty.

Several coinfections of A H1N1pdm09 and seasonal A H1N1 or A H3N2 viruses fundajentos been observed, but no reassortant viruses have been described in humans, suggesting a lack of fitness of reassortant viruses or a lack of opportunities for interaction of different viral lineages.


In contrast, multiple reassortment events have been detected in swine populations between A H1N1 pdm09 and contqbilidad endemic swine viruses. Somewhat surprisingly, many of the well characterized influenza virus virulence markers appear to have limited impact on the phenotype of the A H1N1pdm09 viruses when they have been introduced into mutant viruses in laboratory settings. As such, it is unclear what the evolutionary path of the pandemic virus will be, but the monitoring of any iairo in the circulating viruses will remain a global dundamentos and animal health priority.

Novel Morphocytological Findings in Bronchoalveolar Lavage. Via transmission electron microscopy, these cells were classified as atypical type II pneumocytes and some of them showed cytoplasmic vesicles and inclusions. Outcomes of influenza A H1N1 pdm09 virus infection.

Data from contabiliddad planned cohort studies on risk of major clinical outcomes and prognostic factors for contabilicad with influenza A H1N1 pdm09 virus are limited. Inin order to assess outcomes and evaluate risk factors for progression of illness, two cohort studies were An Exploratory System Dynamics Approach. This paper presents a small exploratory System Dynamics model related to the dynamics of the flu pandemic, also known as the Mexican flu, swine flu, or A H1N1 v.

The model was developed clntabilidad May in order contabilidd quickly foster understanding about the possible dynamics of this new flu variant and. The jairro pandemic is a global outbreak of a new strain of H1N1 influenza virus.

Pandemic influenza A H1N1 has posed a serious public health challenge world-wide. Out tooro collected samples, Among the influenza A positive samples, Results Out of collected samples, Entry screening for influenza A H1N1 pdm09 at Auckland International Airport, New Fundamfntos, detected 4 cases, which were later confirmed, amongpassengers arriving April 27—June 22, Effectiveness of A H1N1 pdm09 influenza vaccine in adults recommended for annual influenza vaccination.

Because of variability in published A H1N1 pdm09 influenza vaccine effectiveness estimates, we conducted a study in the adults belonging to the risk groups to assess the A H1N1 pdm09 MFadjuvanted influenza vaccine effectiveness.

The biological or social mechanisms responsible for the observed age-specific risk of infection are still to be deeply investigated. The antibody titres were measured by fundamenros haemagglutination inhibition HI assay. To estimate age-specific susceptibility to infection we used an age-structured SEIR model.

By comparing pre- and post-pandemic serological data in Italy we found age- specific attack rates similar to those observed in other countries.

Modeling results allow ruling out the hypothesis that only age-specific characteristics of the contact network and levels of pre-pandemic immunity are responsible for the observed age-specific risk of infection. This means that age-specific susceptibility to infection, suspected to play an important role in the pandemic, was not only determined by pre-pandemic levels of H1N1pdm antibody measured by HI.

Our results claim for new studies to better identify the biological mechanisms, which might have determined the observed pattern of susceptibility with age. Moreover, our results highlight the need to obtain early estimates of differential susceptibility with age in any future pandemics to obtain more reliable real time estimates of critical epidemiological parameters. We sought to improve our understanding of these behaviors.

nueva gripe ah1n1: Topics by

To characterize this behavior, we surveyed students in grades and parents of students in grades about student activities during a week long closure of a school during the first months after the disease emerged. We found significant interaction with the community and other students-though less interaction with other students than during school-with the level of interaction increasing with grade. Our results are useful for the future design of social distancing policies and to improving the ability of modeling studies to accurately predict their impact.

Emerging infectious diseases EIDs pose international security threats because of their potential to inflict harm upon humans, crops, livestock, health infrastructure, and economies. Despite the scale of this threat, there are inherent limitations in preventing and controlling EIDs, including the scope of current disease surveillance efforts. All of this leads to the following questions in the context of Mexico’s recent swine flu experience: By way of comparison, what can we learn from the U.

Research provides notable observations-based on the strengths and weaknesses of each country’s response–that can be used as a starting point of discussion for the design of effective EIDs surveillance programs in developing and middle-income countries.


Mexico’s strongest characteristics were its transparency, as well as the cooperation the country exhibited with other nations, particularly the U. While Mexico showed savvy in its effective management of public and media relations, as the article details, political, economic, and cultural problems persisted. Effectiveness of the influenza a H1N1 PDM09 vaccine in adults recommended for annual influenza vaccination: Because of variability in published A H1N1 pdm09 influenza vaccine effectiveness estimates, we aimed to assess the effectiveness of MFadjuvanted A H1N1 pdm09 vaccine in a matched case-control study.

In this study we analyzed the epidemiological patterns of the pandemic during April-December in Mexico and evaluated the impact of nonmedical interventions, school cycles, and demographic factors on influenza transmission. We also estimated the reproduction number R on the basis of the growth rate of daily cases, and used a transmission model to evaluate the effectiveness of mitigation strategies initiated during the spring pandemic wave.

A three-wave pandemic profile was identified, with an initial wave in April-May Mexico City area, a second wave in June-July southeastern states, and a geographically widespread third wave in August-December.

In Finland, the first infections caused by the pandemic too A H1N1 virus were identified on May During the next three months almost all infections were found from patients who had recently traveled abroad. In September the pandemic virus started to spread in the general population, leading to localized outbreaks and peak epidemic activity was reached during weeks The nucleotide sequences of the hemagglutinin HA and neuraminidase NA genes from viruses collected from patients were determined.

The analyzed viruses represented mild and severe infections and different geographic regions and time periods. Most amino acid changes in HA and NA molecules funda,entos on the surface of the molecule and were partly located in antigenic sites. Three severe infections were detected with a mutation at HA residuein two viruses with a change DG, and in torl virus DY. Also viruses with change DE were identified.

All Finnish pandemic viruses were sensitive to oseltamivir having the amino acid histidine at residue of the neuraminidase molecule. Neither in the HA nor in the NA were changes identified that may lead to the selection of a virus with increased epidemic potential or exceptionally high virulence.

Catálogo general 2012 Editorial Universidad del Rosario

Full Text Available Abstracts Background Hemodialysis HD patients have multiple causes of immune dysfunction and poor immune response to influenza vaccination. Methods A total of HD patients were vaccinated with a monovalent adjuvanted H1N1 inactivated influenza vaccine. Seventeen out of HD patients The remaining 97 baseline sero-negative patients were included in contbailidad analysis.

Results Only 30 Further studies are needed to improve the efficacy of vaccination in these high risk patients. Methods Elapsed days between date of flight arrival funddamentos the date passenger lists became available contact details identified – CI was used as proxy for timeliness of CT. In a retrospective study, dates of flight arrival, onset of illness, laboratory diagnosis, CT request and identification of contacts details through passenger lists, following CT requests to the RIVM for toto landed at Schiphol Airport were collected and analyzed.

Results 24 requests for CT were identified. Three of these were declined as over 4 days had elapsed since flight arrival. The average delay between arrival and CI was 3,9 days rangemainly caused by delay in diagnosis of the index patient after arrival 2,6 days. Jario had little additional value for alerting passengers for disease symptoms, as this information already was provided during and after the flight.

Public health authorities should take into account patient delays in seeking medical advise and laboratory confirmation in relation to maximum time to provide fundxmentos prophylaxis when deciding to install contact tracing measures. International standardization of CT guidelines is recommended.

One of them showed severe scoliosis.